SCHEMBL24304380

SCHEMBL24304380

CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC[C@H]1O[C@@](C#N)(c2ccc3c(N)ncnn23)[C@H](O)[C@@H]1O)OCc1ccc(C#N)cc1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TMPRSS2 O15393 1/20 0.38
▸ PLA2G10 O15496 2/20 0.34
▸ PLA2G1B P04054 2/20 0.34
▸ PLA2G2A P14555 2/20 0.34
▸ PLA2G5 P39877 2/20 0.34
▸ POLRMT O00411 1/20 0.31
▸ ADK P55263 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24304704 1.00 TMPRSS2 (0.38) TMPRSS2PLA2G10PLA2G1BPLA2G2APLA2G5
SCHEMBL24304612 1.00 TMPRSS2 (0.38) TMPRSS2PLA2G10PLA2G1BPLA2G2APLA2G5
SCHEMBL24304663 0.96 TMPRSS2 (0.36) TMPRSS2PLA2G10PLA2G1BPLA2G2APLA2G5
SCHEMBL24305050 0.95 TMPRSS2 (0.38) TMPRSS2POLRMTADK
SCHEMBL24305332 0.95 TMPRSS2 (0.38) TMPRSS2PLA2G10PLA2G1BPLA2G2APLA2G5
SCHEMBL24304440 0.95 TMPRSS2 (0.38) TMPRSS2POLRMTADK
SCHEMBL24305344 0.95 TMPRSS2 (0.37) TMPRSS2POLRMTADK
SCHEMBL24304594 0.94 TMPRSS2 (0.38) TMPRSS2POLRMTADK
SCHEMBL24305010 0.94 TMPRSS2 (0.38) TMPRSS2POLRMTADK
SCHEMBL24304910 0.94 TMPRSS2 (0.38) TMPRSS2POLRMTADK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12594292-B2 Antiviral prodrugs, intermediate-and long-acting formulations and methods THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-04-07 — — US disclosed
US-12473314-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2025-11-18 — — US disclosed
US-20250177428-A1 ANTIVIRAL PRODRUGS, INTERMEDIATE-AND LONG-ACTING FORMULATIONS AND METHODS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-06-05 — — US disclosed
EP-4537828-A2 PHOSPHOLIPID COMPOUNDS AND USES THEREOF Gilead Sciences, Inc. (US) 2025-04-16 — — EP disclosed
EP-4200301-B1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES INC (US) 2025-02-26 — — EP disclosed
WO-2024159117-A1 ANTIVIRAL PRODRUGS, INTERMEDIATE-AND LONG-ACTING FORMULATIONS, AND METHODS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-08-02 — — WO disclosed
US-12030904-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2024-07-09 — — US disclosed
US-12030904-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2024-07-09 — — US disclosed
US-12030904-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2024-07-09 — — US disclosed
US-20240025932-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. 2024-01-25 — — US disclosed
US-11773122-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES. INC. (US) 2023-10-03 — — US disclosed
US-11773122-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES. INC. (US) 2023-10-03 — — US disclosed
US-11773122-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES. INC. (US) 2023-10-03 — — US disclosed
US-20230250117-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. 2023-08-10 — — US disclosed
US-20230250117-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. 2023-08-10 — — US disclosed
US-20230250117-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. 2023-08-10 — — US disclosed
EP-4200301-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2023-06-28 — — EP disclosed
US-20220081455-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. 2022-03-17 — — US disclosed
US-20220081455-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. 2022-03-17 — — US disclosed
WO-2022046631-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2022-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12594292-B2 Antiviral prodrugs, intermediate-and long-acting formulations and methods ACE2, SARS1, FURIN TMPRSS2 6/4885PLA2G10 1342/4885PLA2G1B 1589/4885
US-12030904-B2 Phospholipid compounds and uses thereof PHOSPHO1, SGMS2, SGMS1 TMPRSS2 310/4885PLA2G10 31/4885PLA2G1B 22/4885
US-20230250117-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF PHOSPHO1, SGMS2, SGMS1 TMPRSS2 310/4885PLA2G10 31/4885PLA2G1B 22/4885
US-20220081455-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF PHOSPHO1, SGMS2, SGMS1 TMPRSS2 310/4885PLA2G10 31/4885PLA2G1B 22/4885
US-20240025932-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF PHOSPHO1, SGMS2, SGMS1 TMPRSS2 310/4885PLA2G10 31/4885PLA2G1B 22/4885
US-20250177428-A1 ANTIVIRAL PRODRUGS, INTERMEDIATE-AND LONG-ACTING FORMULATIONS AND METHODS SARS1, ACE2, FURIN TMPRSS2 8/4885PLA2G10 1158/4885PLA2G1B 1362/4885
US-11773122-B2 Phospholipid compounds and uses thereof PHOSPHO1, SGMS2, SGMS1 TMPRSS2 310/4885PLA2G10 31/4885PLA2G1B 22/4885
US-12473314-B2 Phospholipid compounds and uses thereof PHOSPHO1, SGMS2, SGMS1 TMPRSS2 310/4885PLA2G10 31/4885PLA2G1B 22/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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