Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21299130 | 0.86 | HRH3 (0.51) | HRH3GPR119AKR1C3ALDH1A1HPGD | |
| SCHEMBL24307894 | 0.86 | HRH3 (0.53) | HRH3AKR1C3ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21299126 | 0.85 | HRH3 (0.52) | HRH3AKR1C3ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21299070 | 0.84 | HRH3 (0.51) | HRH3GPR119AKR1C3ALDH1A1HPGD | |
| SCHEMBL24307884 | 0.81 | HRH3 (0.48) | HRH3GPR119AKR1C3ALDH1A1HPGD | |
| SCHEMBL24307755 | 0.81 | HRH3 (0.48) | HRH3AKR1C3ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24308105 | 0.80 | AKR1C3 (0.43) | HRH3AKR1C3ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21299020 | 0.77 | HRH3 (0.55) | HRH3AKR1C3ALDH1A1HPGDMAPT | |
| SCHEMBL5483871 | 0.76 | ALDH1A1 (0.64) | ALDH1A1HPGDSMN1; SMN2MAPTGAA | |
| SCHEMBL23168357 | 0.74 | HRH3 (0.60) | HRH3GPR119AKR1C3HRH1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3585775-B1 | AZETIDINE COMPOUNDS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS | SANOFI SA (FR) | 2022-04-06 | — | — | EP | disclosed |