Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | NPM1 | P06748 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 4/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.31 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.30 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309562 | 0.95 | FLT4 (0.32) | MAPK7ALKINSRNPM1FLT4 | |
| SCHEMBL24310092 | 0.90 | MAP4K1 (0.31) | — | |
| SCHEMBL24309548 | 0.84 | SCN9A (0.34) | MAPK7ALKFLT4PTK2TNK2 | |
| SCHEMBL29566769 | 0.84 | SCN9A (0.34) | MAPK7ALKFLT4PTK2TNK2 | |
| SCHEMBL24310531 | 0.82 | CTSC (0.32) | — | |
| SCHEMBL24310776 | 0.81 | CTSC (0.37) | PTK2TNK2 | |
| SCHEMBL24310186 | 0.80 | CTSC (0.35) | ALKPTK2TNK2CCND3CDK6 | |
| SCHEMBL24310535 | 0.80 | PTK2 (0.31) | PTK2 | |
| SCHEMBL24309974 | 0.79 | MAP4K1 (0.32) | — | |
| SCHEMBL24309785 | 0.79 | MAP4K1 (0.33) | TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |