Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 3/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309815 | 0.91 | JAK2 (0.34) | JAK2JAK1IGF1RCDK19ALK | |
| SCHEMBL24309836 | 0.89 | JAK2 (0.33) | JAK2JAK1IGF1RCDK19ALK | |
| SCHEMBL24309576 | 0.87 | JAK2 (0.33) | JAK2JAK1 | |
| SCHEMBL24310692 | 0.87 | JAK2 (0.33) | JAK2JAK1IGF1R | |
| SCHEMBL24309833 | 0.86 | JAK2 (0.32) | JAK2JAK1 | |
| SCHEMBL24309404 | 0.86 | CNR1 (0.35) | JAK2JAK1CNR1CNR2 | |
| SCHEMBL24310486 | 0.86 | JAK2 (0.32) | JAK2JAK1 | |
| SCHEMBL24309390 | 0.85 | JAK2 (0.31) | JAK2JAK1 | |
| SCHEMBL24310454 | 0.84 | JAK2 (0.31) | JAK2 | |
| SCHEMBL24309830 | 0.83 | IGF1R (0.32) | JAK2JAK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |