Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309378 | 0.93 | IGF1R (0.30) | — | |
| SCHEMBL24309917 | 0.83 | MAPK14 (0.33) | MAPK14 | |
| SCHEMBL24309882 | 0.82 | MAP4K1 (0.37) | BRD4 | |
| SCHEMBL24309830 | 0.81 | IGF1R (0.32) | MAPK14 | |
| SCHEMBL29566707 | 0.81 | HTR1A (0.39) | MAPK14BRD4 | |
| SCHEMBL24309798 | 0.81 | HTR1A (0.39) | MAPK14BRD4 | |
| SCHEMBL24309848 | 0.80 | IGF1R (0.32) | — | |
| SCHEMBL24310217 | 0.80 | HTR1A (0.31) | — | |
| SCHEMBL24309901 | 0.80 | IGF1R (0.33) | — | |
| SCHEMBL24310179 | 0.80 | IGF1R (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |