Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.33 |
| ▸ | NUAK2 | Q9H093 | 2/20 | 0.33 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 2/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | BLK | P51451 | 1/20 | 0.31 |
| ▸ | BMX | P51813 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310344 | 0.88 | DYRK1A (0.32) | — | |
| SCHEMBL24310359 | 0.86 | BRD9 (0.34) | BRD4BRPF1BRD9 | |
| SCHEMBL24309863 | 0.85 | HTR2C (0.38) | EGFRNUAK2NUAK1GUSBJAK2 | |
| SCHEMBL29567148 | 0.85 | HTR2C (0.38) | EGFRNUAK2NUAK1GUSBJAK2 | |
| SCHEMBL24310615 | 0.84 | MAP4K1 (0.33) | — | |
| SCHEMBL24310686 | 0.79 | BRD4 (0.38) | EGFRNUAK2NUAK1CTSCHRH4 | |
| SCHEMBL24309916 | 0.78 | EGFR (0.39) | EGFRNUAK2NUAK1CTSCHRH4 | |
| SCHEMBL24309710 | 0.78 | FLT4 (0.30) | — | |
| SCHEMBL24309738 | 0.78 | BRD4 (0.34) | JAK2BRD4BRPF1BRD9 | |
| SCHEMBL29567005 | 0.78 | BRD4 (0.34) | JAK2BRD4BRPF1BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |