Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.39 |
| ▸ | CTSC | P53634 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | BLK | P51451 | 2/20 | 0.37 |
| ▸ | BMX | P51813 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.36 |
| ▸ | NUAK2 | Q9H093 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.36 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.36 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.36 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310424 | 0.92 | PDE2A (0.41) | EGFRCTSCJAK2BLKBMX | |
| SCHEMBL24310153 | 0.90 | CTSC (0.36) | EGFRCTSCJAK2BLKBMX | |
| SCHEMBL24309843 | 0.89 | CTSC (0.41) | EGFRCTSCJAK2JAK3IGF1R | |
| SCHEMBL24310715 | 0.88 | CSF1R (0.35) | EGFRCTSCJAK2JAK3IGF1R | |
| SCHEMBL24310686 | 0.88 | BRD4 (0.38) | EGFRCTSCNUAK1NUAK2IGF1R | |
| SCHEMBL24310709 | 0.86 | DRD2 (0.33) | EGFRJAK2IGF1RMAP4K1 | |
| SCHEMBL24309901 | 0.83 | IGF1R (0.33) | JAK2IGF1R | |
| SCHEMBL29567464 | 0.83 | HTR1A (0.41) | EGFRCTSCJAK2BLKBMX | |
| SCHEMBL26808930 | 0.83 | HTR1A (0.41) | EGFRCTSCJAK2BLKBMX | |
| SCHEMBL24310733 | 0.82 | IGF1R (0.34) | IGF1RFLT3MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |