Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.32 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309392 | 0.88 | BRD4 (0.37) | IGF1RMAP4K1 | |
| SCHEMBL24309929 | 0.88 | MAP4K1 (0.33) | IGF1RMAP4K1MAP4K3 | |
| SCHEMBL24310733 | 0.88 | IGF1R (0.34) | IGF1RMAP4K1MAP4K3 | |
| SCHEMBL24309840 | 0.87 | MAP4K1 (0.32) | IGF1RMAP4K1MAP4K3 | |
| SCHEMBL24309769 | 0.86 | MAP4K1 (0.32) | IGF1RMAP4K1MAP4K3 | |
| SCHEMBL24309869 | 0.86 | CHEK1 (0.33) | IGF1RMAP4K1MAP4K3 | |
| SCHEMBL24310201 | 0.86 | MAP4K1 (0.32) | IGF1RMAP4K1MAP4K3 | |
| SCHEMBL24309894 | 0.84 | HTR1A (0.35) | ALK | |
| SCHEMBL29567371 | 0.84 | HTR1A (0.35) | ALK | |
| SCHEMBL24310088 | 0.84 | IGF1R (0.31) | IGF1RMAP4K1MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |