Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.34 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310153 | 0.87 | CTSC (0.36) | IGF1RMAP4K1BRD4 | |
| SCHEMBL24310201 | 0.86 | MAP4K1 (0.32) | IGF1RMAP4K1BRD4MAP4K3 | |
| SCHEMBL24309551 | 0.86 | FYN (0.32) | — | |
| SCHEMBL24309769 | 0.85 | MAP4K1 (0.32) | IGF1RMAP4K1MAP4K3 | |
| SCHEMBL29566986 | 0.85 | SCN9A (0.40) | DYRK1ACLK1CLK2HIPK1HIPK2 | |
| SCHEMBL24310224 | 0.85 | SCN9A (0.40) | DYRK1ACLK1CLK2HIPK1HIPK2 | |
| SCHEMBL24310485 | 0.84 | DRD2 (0.33) | — | |
| SCHEMBL24310158 | 0.82 | MAP4K1 (0.37) | IGF1RMAP4K1BRD4 | |
| SCHEMBL24309929 | 0.82 | MAP4K1 (0.33) | DYRK1AGSK3BIGF1RMAP4K1MAP4K3 | |
| SCHEMBL24310733 | 0.82 | IGF1R (0.34) | IGF1RMAP4K1MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |