Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887307 | 0.90 | BLM (0.59) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL11913784 | 0.90 | BLM (0.59) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL10537164 | 0.88 | BLM (0.63) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL5878892 | 0.88 | BLM (0.63) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL277518 | 0.88 | BLM (0.63) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL1116070 | 0.88 | BLM (0.63) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL27601852 | 0.88 | BLM (0.63) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL10599018 | 0.84 | BLM (0.63) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL5879060 | 0.84 | BLM (0.63) | BLMLMNAMAPTPTPN1KDM4C | |
| SCHEMBL7585177 | 0.84 | BLM (0.57) | BLMLMNAMAPTPTPN1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074866-A1 | MODIFIED AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. | 2025-03-06 | — | — | US | disclosed |
| CN-119285480-A | Modified amine lipids | 英特利亚治疗股份有限公司 | 2025-01-10 | — | — | CN | disclosed |
| US-12077483-B2 | Modified amine lipids | INTELLIA THERAPEUTICS, INC. (US) | 2024-09-03 | — | — | US | disclosed |
| US-20220119341-A1 | MODIFIED AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. | 2022-04-21 | — | — | US | disclosed |
| US-20220119341-A1 | MODIFIED AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. | 2022-04-21 | — | — | US | disclosed |
| CN-113260607-A | Modified amine lipids | 英特利亚治疗股份有限公司 | 2021-08-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12077483-B2 | Modified amine lipids | PHOSPHO1, SGMS1, SGMS2 | BLM 1522/4885LMNA 1381/4885MAPT 1537/4885 |
| US-20220119341-A1 | MODIFIED AMINE LIPIDS | PHOSPHO1, SGMS1, SGMS2 | BLM 1522/4885LMNA 1381/4885MAPT 1537/4885 |
| US-20250074866-A1 | MODIFIED AMINE LIPIDS | PHOSPHO1, SGMS1, SGMS2 | BLM 1522/4885LMNA 1381/4885MAPT 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.