Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2430033 | 0.94 | TP53 (0.34) | TP53KDM4E | |
| SCHEMBL2432141 | 0.94 | TP53 (0.34) | TP53KDM4E | |
| SCHEMBL2427793 | 0.93 | TP53 (0.32) | HRH3TP53KDM4E | |
| SCHEMBL2439849 | 0.93 | HRH3 (0.36) | HRH3TP53KDM4E | |
| SCHEMBL2429692 | 0.84 | KDM4E (0.41) | TP53KDM4E | |
| SCHEMBL2432266 | 0.84 | KDM4E (0.38) | TP53KDM4E | |
| SCHEMBL2437542 | 0.84 | KDM4E (0.41) | TP53KDM4E | |
| SCHEMBL2434844 | 0.80 | SIGMAR1 (0.31) | — | |
| SCHEMBL2426781 | 0.78 | SIGMAR1 (0.31) | — | |
| SCHEMBL2436300 | 0.77 | CYP3A4 (0.37) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212946-A1 | Quinolone Neuropeptide S Receptor Antagonists | MERCK SHARP & DOHME LLC | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212946-A1 | Quinolone Neuropeptide S Receptor Antagonists | NPSR1, NPY1R, NPY2R | HRH3 254/4885TP53 4629/4885KDM4E 4352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.