Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178605 | 0.90 | TGFBR1 (0.70) | TGFBR1LOXL2MAPK14MAPKAPK2HPGDS | |
| SCHEMBL6180820 | 0.83 | TGFBR1 (0.48) | TGFBR1MAPK14KMT2AMEN1 | |
| SCHEMBL374931 | 0.82 | TGFBR1 (0.62) | TGFBR1LOXL2MAPK14MAPKAPK2KDM4E | |
| SCHEMBL29831833 | 0.82 | TGFBR1 (0.62) | TGFBR1LOXL2MAPK14MAPKAPK2KDM4E | |
| SCHEMBL373292 | 0.82 | TGFBR1 (0.66) | TGFBR1MAPK14KDM4E | |
| SCHEMBL6179158 | 0.81 | TGFBR1 (0.53) | TGFBR1MAPK14HPGDS | |
| SCHEMBL12444984 | 0.81 | TGFBR1 (0.57) | TGFBR1MAPK14MAPKAPK2KDM4E | |
| SCHEMBL373524 | 0.80 | TGFBR1 (0.70) | TGFBR1MAPK14MAPKAPK2 | |
| SCHEMBL29358505 | 0.80 | TGFBR1 (0.70) | TGFBR1MAPK14MAPKAPK2 | |
| Water SCHEMBL21633982 | 0.79 | TGFBR1 (0.69) | TGFBR1MAPK14MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076905-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |