Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 13/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29456349 | 1.00 | CRHBP (0.45) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL21516347 | 1.00 | CRHBP (0.45) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL29456514 | 1.00 | CRHBP (0.45) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL21516338 | 1.00 | CRHBP (0.45) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL24313462 | 0.89 | CRHBP (0.47) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL24313225 | 0.89 | NTRK1 (0.49) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL24313227 | 0.87 | CRHBP (0.45) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL24313314 | 0.87 | CRHBP (0.45) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL21517032 | 0.85 | CRHBP (0.43) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL21516317 | 0.85 | CRHBP (0.43) | CRHBPCRHR2SMN1; SMN2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4043460-A1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | Merck Patent GmbH (DE) | 2022-08-17 | — | — | EP | disclosed |
| EP-3784666-B1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-03-16 | — | — | EP | disclosed |
| CN-112236428-A | Antiproliferative compounds and uses thereof | 默克专利股份有限公司 | 2021-01-15 | — | — | CN | disclosed |