Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29456495 | 0.89 | KMT2A (0.43) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL21491449 | 0.89 | KMT2A (0.43) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL21491303 | 0.87 | CA12 (0.44) | PDE4DPDE4APDE4BPDE4CMAPT | |
| Hydrochloric Acid SCHEMBL29456315 | 0.86 | CA12 (0.43) | PDE4DPDE4APDE4BPDE4CMAPT | |
| Hydrochloric Acid SCHEMBL21491110 | 0.86 | CA12 (0.43) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL24313112 | 0.82 | SCN9A (0.39) | SLC6A2SLC6A4SLC6A3CLK1CLK2 | |
| SCHEMBL21491317 | 0.75 | ALDH1A1 (0.41) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL21491473 | 0.73 | ALDH1A1 (0.39) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL22516364 | 0.72 | MEN1 (0.49) | CCNCCDK8PLK1PDE4DPDE4A | |
| SCHEMBL25482905 | 0.72 | TSHR (0.37) | KMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4043460-A1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | Merck Patent GmbH (DE) | 2022-08-17 | — | — | EP | disclosed |
| EP-3784666-B1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-03-16 | — | — | EP | disclosed |