Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313515 | 0.90 | CRHBP (0.50) | CRHBPCRHR2SMN1; SMN2HRH4HRH3 | |
| SCHEMBL24313097 | 0.83 | CRHBP (0.47) | CRHBPCRHR2SMN1; SMN2HRH4HRH3 | |
| SCHEMBL21516639 | 0.81 | CRHBP (0.40) | CRHBPCRHR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24313314 | 0.81 | CRHBP (0.45) | CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL21491330 | 0.80 | CRHBP (0.48) | CRHBPCRHR2SMN1; SMN2HRH4HRH3 | |
| SCHEMBL21491441 | 0.80 | CRHBP (0.48) | CRHBPCRHR2SMN1; SMN2HRH4HRH3 | |
| SCHEMBL21491331 | 0.80 | CRHBP (0.48) | CRHBPCRHR2SMN1; SMN2HRH4HRH3 | |
| SCHEMBL29849049 | 0.80 | CRHBP (0.48) | CRHBPCRHR2SMN1; SMN2HRH4HRH3 | |
| SCHEMBL29456542 | 0.80 | CRHBP (0.48) | CRHBPCRHR2SMN1; SMN2HRH4HRH3 | |
| SCHEMBL24313218 | 0.80 | CRHBP (0.43) | CRHBPCRHR2SMN1; SMN2HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4043460-A1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | Merck Patent GmbH (DE) | 2022-08-17 | — | — | EP | disclosed |
| EP-3784666-B1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-03-16 | — | — | EP | disclosed |