⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3203996 | 1.00 | — | — | |
| SCHEMBL5531114 | 1.00 | — | — | |
| SCHEMBL23509836 | 0.78 | — | — | |
| SCHEMBL7261240 | 0.75 | — | — | |
| SCHEMBL7262540 | 0.75 | — | — | |
| SCHEMBL131612 | 0.67 | — | — | |
| SCHEMBL8995158 | 0.60 | — | — | |
| SCHEMBL9668278 | 0.60 | — | — | |
| SCHEMBL890318 | 0.50 | — | — | |
| SCHEMBL834059 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047677-B1 | Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid | BRACCO SPA (IT) | 2005-07-20 | — | — | EP | claimed |
| US-6653470-B1 | Condensing triethylenetetramine with glyoxal hydrate in calcium hydroxide to give 3H,6H-octahydro-2a,5,6,8a-tetraazacenaphthylene; reacting 1,2-dichloroethane; cyclization, salt formation, ring expansion | BRACCO INTERNATIONAL B.V. (NL) | 2003-11-25 | — | — | US | claimed |
| EP-0980360-B1 | A PROCESS FOR THE PREPARATION OF 1,4,7,10-TETRAAZACYCLODODECANE | BRACCO INT BV (NL) | 2002-07-17 | — | — | EP | claimed |
| CN-113453720-B | Dual ligand drug conjugate and uses thereof | 同宜医药（苏州）有限公司 | 2025-05-06 | — | — | CN | disclosed |
| EP-3909948-B1 | BIFUNCTIONAL DO2PA DERIVATIVES, CHELATES WITH METALLIC CATIONS AND USE THEREOF | CENTRE NAT RECH SCIENT (FR) | 2024-02-28 | — | — | EP | disclosed |
| EP-3909948-B1 | BIFUNCTIONAL DO2PA DERIVATIVES, CHELATES WITH METALLIC CATIONS AND USE THEREOF | CENTRE NAT RECH SCIENT (FR) | 2024-02-28 | — | — | EP | disclosed |
| US-20220175761-A1 | BI-LIGAND DRUG CONJUGATE AND USE THEREOF | COHERENT BIOPHARMA SUZHOU LTD (CN) | 2022-06-09 | — | — | US | disclosed |
| US-20220143230-A1 | BIFUNCTIONAL do2pa DERIVATIVES, CHELATES WITH METALLIC CATIONS AND USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2022-05-12 | — | — | US | disclosed |
| US-20220143230-A1 | BIFUNCTIONAL do2pa DERIVATIVES, CHELATES WITH METALLIC CATIONS AND USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2022-05-12 | — | — | US | disclosed |
| US-11266754-B2 | Bifunctional do2pa derivatives, chelates with metallic cations and use thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2022-03-08 | — | — | US | disclosed |
| US-11266754-B2 | Bifunctional do2pa derivatives, chelates with metallic cations and use thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2022-03-08 | — | — | US | disclosed |
| US-6469162-B1 | SUCH COMPOUNDS INHIBIT MAMMALIAN, BACTERIAL, AND FUNGAL CELL REPLICATION AND ARE USEFUL IN THE TREATMENT OF NEOPLASIA, INFECTION, INFLAMMATION, IMMUNE REPONSE, AND IN TERMINATION OF PREGNANCY | CONCAT, LTD. | 2002-10-22 | — | — | US | disclosed |
| EP-0980360-B1 | A PROCESS FOR THE PREPARATION OF 1,4,7,10-TETRAAZACYCLODODECANE | BRACCO INT BV (NL) | 2002-07-17 | — | — | EP | disclosed |
| EP-0973776-B1 | A PROCESS FOR THE PREPARATION OF TETRAAZAMACROCYCLES | BRACCO INT BV (NL) | 2002-07-03 | — | — | EP | disclosed |
| US-6342597-B1 | CONDENSATION REACTION TRIETHYLENETETRAMINE WITH GLYOXAL TO CYCLIZE; OXIDATION, ALKYLATION, HYDROLYSIS, QUATERNIZATION; NUCLEAR MAGNETIC RESONANCE IMAGING | DIBRA S.P.A. (IT) | 2002-01-29 | — | — | US | disclosed |
| WO-2001079207-A2 | A PROCESS FOR THE PREPARATION OF DECAHYDRO-2A,4A,6A,8A-TETRAAZACYCLOPENT[FG]ACENAPHTHYLENE AND FUNCTIONALIZED DERIVATIVES | BRACCO INTERNATIONAL BV (NL) | 2001-10-25 | — | — | WO | disclosed |
| US-6150520-A | AMINATION, DEHYDRATION AND CYCLIZATION | DIBRA S.P.A. (IT) | 2000-11-21 | — | — | US | disclosed |
| CN-1253552-A | Process for preparation of 1,4,7,10-tetraazacyclododecane | BRACCO SPA (IT) | 2000-05-17 | — | — | CN | disclosed |
| EP-0980360-A1 | A PROCESS FOR THE PREPARATION OF 1,4,7,10-TETRAAZACYCLODODECANE | BRACCO INTERNATIONAL B.V. (NL) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049151-A1 | A PROCESS FOR THE PREPARATION OF 1,4,7,10-TETRAAZACYCLODODECANE | BRACCO S.P.A. (IT) | 1998-11-05 | — | — | WO | disclosed |