Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17484615 | 0.87 | PPARA (0.42) | L3MBTL1GRM7GPR3 | |
| SCHEMBL6199816 | 0.82 | FFAR4 (0.39) | GPR3 | |
| SCHEMBL16953616 | 0.81 | PPARD (0.47) | L3MBTL1S1PR1TACR1LMNAMAPT | |
| SCHEMBL6417045 | 0.81 | GPR3 (0.42) | GRM7HCRTR1HCRTR2GPR3 | |
| SCHEMBL8148399 | 0.80 | S1PR1 (0.46) | L3MBTL1S1PR1TACR1GRM7LMNA | |
| SCHEMBL20652692 | 0.80 | KDM4E (0.51) | L3MBTL1S1PR1TACR1GRM7MAPT | |
| SCHEMBL16953615 | 0.80 | S1PR1 (0.43) | L3MBTL1S1PR1TACR1GRM7LMNA | |
| SCHEMBL15515783 | 0.79 | MAPT (0.47) | LMNAMAPTATMNQO1 | |
| SCHEMBL25354042 | 0.78 | PPARD (0.51) | — | |
| SCHEMBL5785776 | 0.78 | FFAR1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |