SCHEMBL24313681

SCHEMBL24313681

CN1CC[C@H](NC(=O)[C@H]2O[C@@H](n3cc(-c4ccn(C)n4)c4c(N)ncnc43)[C@H](O)[C@@H]2O)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ METTL3 Q86U44 17/20 1.00
▸ PRMT5 O14744 16/20 1.00
▸ WDR77 Q9BQA1 16/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24314245 1.00 METTL3 (1.00) METTL3PRMT5WDR77
SCHEMBL24313599 0.95 PRMT5 (1.00) METTL3PRMT5WDR77
SCHEMBL29611811 0.95 PRMT5 (1.00) METTL3PRMT5WDR77
SCHEMBL24314174 0.95 PRMT5 (1.00) METTL3PRMT5WDR77
SCHEMBL24313656 0.94 METTL3 (1.00) METTL3PRMT5WDR77
SCHEMBL24314240 0.89 PRMT5 (1.00) METTL3PRMT5WDR77
SCHEMBL24313662 0.89 METTL3 (0.86) METTL3PRMT5WDR77
SCHEMBL24313657 0.89 METTL3 (0.86) METTL3PRMT5WDR77
SCHEMBL24314172 0.89 METTL3 (1.00) METTL3PRMT5WDR77
SCHEMBL24314144 0.89 METTL3 (1.00) METTL3PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022081739-A1 METTL3 MODULATORS ACCENT THERAPEUTICS, INC. (US) 2022-04-21 — — WO disclosed
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