SCHEMBL24314142

SCHEMBL24314142

CN(C)CCNC(=O)[C@H]1O[C@@H](n2cc(-c3ccn(C)n3)c3c(N)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 9/20 1.00
▸ WDR77 Q9BQA1 9/20 1.00
▸ METTL3 Q86U44 15/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24314243 0.95 PRMT5 (1.00) PRMT5WDR77METTL3
SCHEMBL24314139 0.89 PRMT5 (0.80) PRMT5WDR77METTL3
SCHEMBL24313586 0.88 PRMT5 (0.78) PRMT5WDR77METTL3
SCHEMBL24313854 0.88 METTL3 (1.00) PRMT5WDR77METTL3
SCHEMBL24314173 0.87 METTL3 (0.77) PRMT5WDR77METTL3
SCHEMBL24313604 0.87 METTL3 (1.00) PRMT5WDR77METTL3
SCHEMBL24313596 0.87 METTL3 (1.00) PRMT5WDR77METTL3
SCHEMBL24313679 0.86 PRMT5 (0.81) PRMT5WDR77METTL3
SCHEMBL24313602 0.86 METTL3 (1.00) PRMT5WDR77METTL3
SCHEMBL24313648 0.86 METTL3 (1.00) PRMT5WDR77METTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022081739-A1 METTL3 MODULATORS ACCENT THERAPEUTICS, INC. (US) 2022-04-21 — — WO disclosed
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