Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24170476 | 0.95 | DRD2 (0.42) | CYP2D6KMT2ACARM1PRMT6PRMT8 | |
| SCHEMBL6740305 | 0.92 | DRD2 (0.46) | DRD2SIGMAR1DRD3 | |
| SCHEMBL16169890 | 0.92 | CARM1 (0.48) | CARM1PRMT6PRMT8DRD2SIGMAR1 | |
| SCHEMBL84804 | 0.92 | DRD2 (0.46) | DRD2SIGMAR1DRD3 | |
| SCHEMBL6660808 | 0.92 | DRD2 (0.46) | DRD2SIGMAR1DRD3 | |
| SCHEMBL19546252 | 0.92 | DRD2 (0.46) | DRD2SIGMAR1DRD3 | |
| SCHEMBL19546735 | 0.92 | DRD2 (0.46) | DRD2SIGMAR1DRD3 | |
| SCHEMBL20363772 | 0.89 | CARM1 (0.46) | CARM1PRMT6PRMT8DRD2SIGMAR1 | |
| SCHEMBL10294630 | 0.89 | CYP2D6 (0.46) | CYP2D6KMT2ACARM1PRMT6PRMT8 | |
| SCHEMBL60012 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |