Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26620516 | 0.91 | TSHR (0.56) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL27010446 | 0.86 | ALDH1A1 (0.58) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL24316062 | 0.84 | TSHR (0.58) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL27010323 | 0.81 | ALDH1A1 (0.57) | TSHRALDH1A1KDM4EUSP2HSD17B10 | |
| SCHEMBL26620219 | 0.81 | TSHR (0.64) | TSHRALDH1A1KDM4EUSP2LMNA | |
| SCHEMBL24317323 | 0.81 | NPC1 (0.43) | TSHRALDH1A1USP2SMN1; SMN2GAA | |
| SCHEMBL24317304 | 0.80 | TSHR (0.60) | TSHRALDH1A1KDM4EUSP2LMNA | |
| SCHEMBL26620513 | 0.80 | TSHR (0.60) | TSHRALDH1A1KDM4EUSP2LMNA | |
| SCHEMBL26635523 | 0.80 | TSHR (0.54) | TSHRALDH1A1KDM4EUSP2LMNA | |
| SCHEMBL26636731 | 0.79 | TSHR (0.58) | TSHRALDH1A1KDM4EUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |