Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KIF5B | P33176 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30782464 | 0.75 | KMT2A (0.54) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL1478679 | 0.75 | KMT2A (0.54) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL30530531 | 0.74 | EGFR (0.55) | EGFRKMT2AMEN1AURKANR2F2 | |
| SCHEMBL24329543 | 0.74 | EGFR (0.55) | EGFRKMT2AMEN1AURKANR2F2 | |
| SCHEMBL1014181 | 0.72 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8808732 | 0.71 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL17823198 | 0.69 | ENPP1 (0.48) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL1192699 | 0.69 | KDM1A (0.45) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL24329542 | 0.69 | PARP1 (0.58) | HPGDNPC1RAB9ADYRK1AMAPT | |
| SCHEMBL9267455 | 0.68 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |