Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31113992 | 1.00 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDPK1 | |
| SCHEMBL8808732 | 0.79 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL17827792 | 0.78 | PDPK1 (0.40) | PDE4APDE4BPDE4CPDE4DPDPK1 | |
| SCHEMBL18312022 | 0.76 | PI4KA (0.48) | PDPK1DYRK1AAXLEGFRBACE1 | |
| SCHEMBL3276096 | 0.76 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL1014181 | 0.76 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL29461096 | 0.76 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL14208280 | 0.76 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| Hydrochloric Acid SCHEMBL4029810 | 0.74 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL29936178 | 0.73 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018021977-A1 | GLYCINE METABOLISM MODULATORS AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-02-01 | — | — | WO | disclosed |
| US-5387585-A | Treating epilepsy, anxiety, sleep disorders, schizophrnia, senile dementia | HOFFMANN-LA ROCHE INC. (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0519307-A2 | Tetracyclic Imidazodiazepines | F. HOFFMANN-LA ROCHE AG (CH) | 1992-12-23 | — | — | EP | disclosed |