Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 9/20 | 0.47 |
| ▸ | GRM5 | P41594 | 8/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30952401 | 0.90 | NAMPT (0.47) | GRM1GRM5NAMPTPDK4CDK7 | |
| SCHEMBL23120656 | 0.85 | NAMPT (0.52) | GRM1GRM5NAMPTPDK4CDK7 | |
| SCHEMBL29223732 | 0.84 | PDK4 (0.46) | GRM1GRM5NAMPTPDK4CDK7 | |
| SCHEMBL31201927 | 0.84 | PDK4 (0.46) | GRM1GRM5NAMPTPDK4CDK7 | |
| SCHEMBL29223716 | 0.83 | SCN9A (0.47) | GRM1GRM5NAMPTPDK4CDK7 | |
| SCHEMBL25167744 | 0.83 | PDK4 (0.51) | GRM1GRM5NAMPTPDK4CDK7 | |
| SCHEMBL30913581 | 0.83 | PDK4 (0.51) | GRM1GRM5NAMPTPDK4CDK7 | |
| SCHEMBL31174297 | 0.81 | NAMPT (0.56) | GRM1GRM5NAMPTPDK4TLR7 | |
| SCHEMBL6366609 | 0.81 | NAMPT (0.56) | GRM1GRM5NAMPTPDK4TLR7 | |
| SCHEMBL15184378 | 0.81 | NAMPT (0.53) | GRM1GRM5NAMPTPDK4TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4204418-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |