Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319188 | 0.84 | NCF1 (0.41) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL24319365 | 0.82 | CACNA2D1 (0.36) | CACNA2D1CACNA1BCACNB1CHRM5ADRA2C | |
| SCHEMBL24319651 | 0.81 | NCF1 (0.38) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL25571706 | 0.80 | NCF1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL23173902 | 0.80 | NCF1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL3436997 | 0.78 | NCF1 (0.52) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL24319476 | 0.76 | NCF1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL22765744 | 0.75 | — | — | |
| SCHEMBL12321702 | 0.74 | NCF1 (0.45) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL27249930 | 0.74 | NCF1 (0.48) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |