Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319163 | 1.00 | KDM4E (0.48) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL10509923 | 0.84 | USP2 (0.49) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL13924017 | 0.83 | KDM4E (0.55) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL11154511 | 0.82 | KDM4E (0.58) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL10005231 | 0.82 | KDM4E (0.64) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL21477058 | 0.80 | KDM4E (0.57) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL21477194 | 0.80 | KDM4E (0.57) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL18551052 | 0.78 | KDM4E (0.58) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL18551060 | 0.78 | KDM4E (0.58) | KDM4EGLAALDH1A1USP2ALOX15 | |
| SCHEMBL26376109 | 0.78 | KDM4E (0.58) | KDM4EGLAALDH1A1USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |