Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18159898 | 1.00 | KDM4E (0.50) | KDM4EGLAGAAMEN1KMT2A | |
| SCHEMBL24319186 | 1.00 | KDM4E (0.50) | KDM4EGLAGAAMEN1KMT2A | |
| SCHEMBL2800684 | 0.91 | KMT2A (0.48) | KDM4EGLAMEN1KMT2AALDH1A1 | |
| SCHEMBL11668191 | 0.91 | — | — | |
| SCHEMBL14078770 | 0.88 | KDM4E (0.47) | KDM4EGLAGAAMEN1KMT2A | |
| SCHEMBL24672708 | 0.85 | SLC18A3 (0.45) | KDM4EGLAMEN1KMT2AALDH1A1 | |
| SCHEMBL11131278 | 0.84 | KDM4E (0.58) | KDM4EGLAGAAMEN1KMT2A | |
| SCHEMBL5825167 | 0.83 | KDM4E (0.39) | KDM4EGLAGAAMEN1KMT2A | |
| SCHEMBL5907323 | 0.83 | KDM4E (0.50) | KDM4EGLAGAAMEN1KMT2A | |
| SCHEMBL24319428 | 0.83 | KDM4E (0.53) | KDM4EGLAGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |