Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10911834 | 0.85 | ALDH1A1 (0.51) | TP53SMN1; SMN2ALDH1A1TSHRHIF1A | |
| SCHEMBL21197712 | 0.85 | PARP10 (0.48) | TP53SMN1; SMN2ALDH1A1TSHRHIF1A | |
| SCHEMBL21197713 | 0.85 | PARP10 (0.48) | TP53SMN1; SMN2ALDH1A1TSHRHIF1A | |
| SCHEMBL22988780 | 0.85 | PARP10 (0.48) | TP53SMN1; SMN2ALDH1A1TSHRHIF1A | |
| SCHEMBL4441810 | 0.83 | CA12 (0.53) | TP53SMN1; SMN2ALDH1A1TSHRHIF1A | |
| SCHEMBL24319688 | 0.81 | KDM4E (0.40) | TP53SMN1; SMN2ALDH1A1TSHRCYP3A4 | |
| SCHEMBL7092195 | 0.81 | TSHR (0.49) | TP53SMN1; SMN2ALDH1A1TSHRHIF1A | |
| SCHEMBL16628428 | 0.79 | ALDH1A1 (0.44) | TP53SMN1; SMN2ALDH1A1TSHRHIF1A | |
| SCHEMBL17197313 | 0.78 | CYP1A2 (0.56) | TP53SMN1; SMN2ALDH1A1CYP3A4MAPT | |
| SCHEMBL6617932 | 0.78 | ALDH1A1 (0.59) | TP53SMN1; SMN2ALDH1A1TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |