SCHEMBL24319665

SCHEMBL24319665

Cc1ccnc2c1ccn2C(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BUB1 O43683 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.36
BCHE P06276 1/20 0.35
HSP90AA1 P07900 1/20 0.35
HSP90AB1 P08238 1/20 0.35
POLB P06746 1/20 0.34
PIK3CD O00329 1/20 0.34
ABL1 P00519 1/20 0.34
EGFR P00533 1/20 0.34
HCK P08631 1/20 0.34
SRC P12931 1/20 0.34
KDR P35968 1/20 0.34
PIK3CA P42336 1/20 0.34
PIK3CB P42338 1/20 0.34
MTOR P42345 1/20 0.34
PIK3CG P48736 1/20 0.34
EPHB4 P54760 1/20 0.34
PRKDC P78527 1/20 0.34
PI4KB Q9UBF8 1/20 0.34
ENPP3 O14638 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29128021 0.86 BUB1 (0.39) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1
SCHEMBL25703228 0.84 BUB1 (0.38) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1
SCHEMBL29522590 0.84 PIK3CA (0.38) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1
SCHEMBL31240726 0.84 ENPP3 (0.48) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1
SCHEMBL2792837 0.84 HSP90AA1 (0.39) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1
SCHEMBL138212 0.84 PIK3CA (0.38) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1
SCHEMBL580658 0.84 ENPP3 (0.48) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1
SCHEMBL30991728 0.84 BUB1 (0.38) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1
SCHEMBL18441417 0.83 BUB1 (0.37) BUB1BCHEHSP90AA1HSP90AB1POLB
SCHEMBL1457357 0.81 HSP90AA1 (0.37) BUB1L3MBTL1BCHEHSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022067106-A1 CRYSTALLINE POLYMORPH FORM A OF A JAK INHIBITOR AND METHODS FOR ITS PREPARATION ACLARIS THERAPEUTICS, INC. (US) 2022-03-31 WO disclosed