Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30704943 | 0.83 | POLB (0.48) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL27157404 | 0.83 | POLB (0.48) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL30656833 | 0.83 | POLB (0.48) | MEN1KMT2APOLBACVR1GAA | |
| SCHEMBL24166072 | 0.83 | POLB (0.48) | MEN1KMT2APOLBACVR1GAA | |
| SCHEMBL27157351 | 0.83 | POLB (0.44) | MEN1KMT2APOLBACVR1GAA | |
| SCHEMBL30047726 | 0.83 | POLB (0.44) | MEN1KMT2APOLBACVR1GAA | |
| SCHEMBL8439313 | 0.82 | POLB (0.60) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL30516956 | 0.82 | POLB (0.60) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL3656842 | 0.81 | MEN1 (0.68) | MEN1KMT2AACVR1GABRA1GABRG2 | |
| SCHEMBL24320130 | 0.81 | IP6K1 (0.46) | MEN1KMT2APOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669769-A | Piperidinyl small molecule degradants of HELIOS and methods of use | 达纳－法伯癌症研究所公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022081976-A1 | PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |