Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439313 | 1.00 | POLB (0.60) | POLBRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL30656833 | 0.82 | POLB (0.48) | POLBRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL30704943 | 0.82 | POLB (0.48) | POLBSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL24320125 | 0.82 | MEN1 (0.52) | POLBSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL27157404 | 0.82 | POLB (0.48) | POLBSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL24166072 | 0.82 | POLB (0.48) | POLBRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL30516949 | 0.80 | IP6K1 (0.46) | POLBRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL24320130 | 0.80 | IP6K1 (0.46) | POLBRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL24320128 | 0.79 | IP6K1 (0.45) | POLBRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL30516952 | 0.79 | IP6K1 (0.45) | POLBRAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669769-A | Piperidinyl small molecule degradants of HELIOS and methods of use | 达纳－法伯癌症研究所公司 | 2023-08-29 | — | — | CN | disclosed |