Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29483023 | 0.88 | JAK3 (0.44) | GPR119KMT2AMEN1SMN1; SMN2CYP2C19 | |
| SCHEMBL22914843 | 0.85 | EGLN2 (0.46) | GPR119JAK3MAPTALDH1A1LMNA | |
| SCHEMBL18291332 | 0.81 | JAK3 (0.47) | GPR119KMT2AMEN1SMN1; SMN2JAK3 | |
| SCHEMBL38651717 | 0.80 | JAK3 (0.42) | GPR119KMT2AMEN1SMN1; SMN2JAK3 | |
| SCHEMBL18186394 | 0.78 | JAK3 (0.46) | GPR119KMT2AMEN1SMN1; SMN2CYP2C19 | |
| SCHEMBL16540062 | 0.77 | JAK3 (0.43) | GPR119SMN1; SMN2JAK3MAPTALDH1A1 | |
| SCHEMBL27031070 | 0.77 | GPR119 (0.60) | GPR119KMT2AMEN1SMN1; SMN2CYP2C19 | |
| SCHEMBL29933261 | 0.75 | GPR119 (0.62) | GPR119KMT2AMEN1SMN1; SMN2CYP2C19 | |
| SCHEMBL22146394 | 0.75 | JAK3 (0.39) | SMN1; SMN2JAK3 | |
| SCHEMBL2056118 | 0.75 | GPR119 (0.77) | GPR119KMT2AMEN1SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |