Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24321302 | 0.92 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1HSP90B1TRAP1PDK1 | |
| SCHEMBL15522473 | 0.89 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1HSP90B1TRAP1PDK1 | |
| SCHEMBL30368851 | 0.89 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1HSP90B1TRAP1PDK1 | |
| Piperazine SCHEMBL28333614 | 0.88 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1HSP90B1TRAP1PDK1 | |
| Hydrochloric Acid SCHEMBL29529693 | 0.88 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1HSP90B1TRAP1PDK1 | |
| Hydrochloric Acid SCHEMBL16569190 | 0.88 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1HSP90B1TRAP1PDK1 | |
| SCHEMBL24321397 | 0.86 | BRD4 (0.43) | HSP90AA1HSP90AB1HSP90B1TRAP1BRD4 | |
| SCHEMBL24321371 | 0.85 | BRD4 (0.42) | HSP90AA1HSP90AB1HSP90B1TRAP1BRD4 | |
| SCHEMBL16981554 | 0.84 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1HSP90B1TRAP1BRD4 | |
| SCHEMBL16569651 | 0.84 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1HSP90B1TRAP1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078414-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) | 2022-04-21 | — | — | WO | disclosed |