Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.42 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24322012 | 0.92 | HSP90AA1 (0.40) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL24321350 | 0.90 | MEN1 (0.47) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL24321184 | 0.90 | HSP90AA1 (0.46) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL24321355 | 0.88 | HSP90AA1 (0.38) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL30385274 | 0.87 | HSP90AA1 (0.50) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL16569651 | 0.86 | HSP90AA1 (0.44) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL24321693 | 0.86 | PDK1 (0.44) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL24321244 | 0.84 | MEN1 (0.46) | HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL30801097 | 0.84 | MEN1 (0.46) | HSP90AA1HSP90B1TRAP1HSP90AB1 | |
| SCHEMBL24321134 | 0.84 | HSP90AA1 (0.47) | HSP90AA1HSP90B1HSP90AB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078414-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) | 2022-04-21 | — | — | WO | disclosed |