Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323074 | 0.87 | MTNR1A (0.34) | MTNR1AMTNR1BHPGDKDM4ENLRP3 | |
| SCHEMBL1488694 | 0.80 | HTR2A (0.46) | HTR2AHRH1KDM4E | |
| SCHEMBL19520637 | 0.79 | MTNR1A (0.54) | MTNR1AMTNR1BHPGD | |
| SCHEMBL23882069 | 0.78 | MTNR1A (0.40) | MTNR1AMTNR1BHPGD | |
| SCHEMBL23732696 | 0.74 | — | — | |
| SCHEMBL13786398 | 0.73 | HDAC6 (0.47) | — | |
| SCHEMBL20505740 | 0.73 | EPHX2 (0.50) | MTNR1AMTNR1B | |
| SCHEMBL29572544 | 0.73 | EPHX2 (0.50) | MTNR1AMTNR1B | |
| SCHEMBL24324570 | 0.73 | — | — | |
| SCHEMBL13786386 | 0.72 | HDAC6 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |