Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25784651 | 0.85 | HDAC2 (0.61) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL12313357 | 0.82 | HDAC2 (0.56) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL26936154 | 0.81 | CYP1A2 (0.55) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL26936166 | 0.80 | HDAC2 (0.53) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL4591710 | 0.80 | RECQL (0.58) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL25784780 | 0.80 | SMN1; SMN2 (0.64) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL428550 | 0.79 | HDAC8 (0.58) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL48869 | 0.79 | POLB (0.60) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL3558312 | 0.77 | MEN1 (0.63) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 | |
| SCHEMBL30208757 | 0.77 | MEN1 (0.63) | HDAC2HDAC8HDAC6KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |