Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATF4 | P18848 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577383 | 1.00 | HSD17B10 (0.45) | HSD17B10POLBATF4PKMNPC1 | |
| SCHEMBL24323139 | 1.00 | HSD17B10 (0.45) | HSD17B10POLBATF4PKMNPC1 | |
| SCHEMBL19577327 | 0.95 | ATF4 (0.44) | HSD17B10POLBATF4PKMNPC1 | |
| SCHEMBL24322824 | 0.95 | ATF4 (0.46) | HSD17B10POLBATF4PKMNPC1 | |
| SCHEMBL19577457 | 0.95 | ATF4 (0.46) | HSD17B10POLBATF4PKMNPC1 | |
| SCHEMBL24323450 | 0.91 | GAA (0.47) | ATF4ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL19577482 | 0.91 | GAA (0.47) | ATF4ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL24322956 | 0.91 | GAA (0.47) | ATF4ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL24324216 | 0.91 | ATF4 (0.49) | ATF4 | |
| SCHEMBL24322885 | 0.91 | ATF4 (0.49) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |