Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569416 | 0.82 | ATF4 (0.86) | ATF4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL20610459 | 0.82 | ATF4 (0.59) | ATF4KMT2AMEN1HPGDMAPT | |
| SCHEMBL20721978 | 0.78 | ATF4 (0.67) | ATF4 | |
| SCHEMBL19569704 | 0.75 | ATF4 (0.70) | ATF4 | |
| SCHEMBL20974142 | 0.74 | ATF4 (1.00) | ATF4KMT2AMEN1ALDH1A1 | |
| SCHEMBL23149159 | 0.73 | ATF4 (0.71) | ATF4KMT2AMEN1HPGDGAA | |
| SCHEMBL19556192 | 0.72 | ATF4 (0.89) | ATF4KMT2AMEN1ALDH1A1 | |
| SCHEMBL20631296 | 0.72 | ATF4 (0.82) | ATF4KMT2AMEN1ALDH1A1 | |
| SCHEMBL19577397 | 0.72 | ATF4 (0.62) | ATF4KMT2AALDH1A1MAPT | |
| SCHEMBL19569249 | 0.72 | ATF4 (0.53) | ATF4KMT2AMEN1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |