SCHEMBL24323302

SCHEMBL24323302

O=Cc1ccc(N2CCOCC2)nn1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
HTT P42858 1/20 0.48
KDM4E B2RXH2 5/20 0.47
LMNA P02545 1/20 0.47
HSD17B10 Q99714 1/20 0.47
CNR2 P34972 8/20 0.47
RAB9A P51151 2/20 0.47
MEN1 O00255 1/20 0.47
NPC1 O15118 1/20 0.47
KMT2A Q03164 1/20 0.47
PKM P14618 1/20 0.46
PIK3CD O00329 1/20 0.43
PIK3CA P42336 1/20 0.43
PIK3CB P42338 1/20 0.43
PIK3CG P48736 1/20 0.43
PRKDC P78527 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5754979 0.83 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2HTTKDM4ELMNA
SCHEMBL4763503 0.83 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2HTTKDM4ELMNA
SCHEMBL1868512 0.75 PDE10A (0.48) ALDH1A1SMN1; SMN2HTTKDM4EHSD17B10
SCHEMBL31310689 0.73 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2HTTKDM4ELMNA
SCHEMBL807738 0.73 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2HTTKDM4ELMNA
SCHEMBL11981452 0.73 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2HTTKDM4ELMNA
SCHEMBL210065 0.73 CYP1A2 (0.67) ALDH1A1SMN1; SMN2HTTKDM4ELMNA
SCHEMBL106639 0.73 MEN1 (0.54) ALDH1A1SMN1; SMN2HTTKDM4ELMNA
SCHEMBL21423998 0.73 BPTF (0.62) ALDH1A1SMN1; SMN2HTTKDM4ELMNA
SCHEMBL5084510 0.73 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2HTTKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4225765-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2023-08-16 EP disclosed
WO-2022076622-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed
WO-2022076622-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed