Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059430 | 0.86 | MEN1 (0.42) | — | |
| SCHEMBL19450068 | 0.79 | POLB (0.51) | TLR2 | |
| SCHEMBL411692 | 0.78 | SCN9A (0.57) | MAPTL3MBTL1SCN9AMAOBMAOA | |
| SCHEMBL1790979 | 0.78 | SCN9A (0.57) | MAPTL3MBTL1SCN9AMAOBMAOA | |
| SCHEMBL1576808 | 0.77 | PDCD1 (0.49) | — | |
| SCHEMBL26523520 | 0.77 | CYP1A2 (0.47) | TLR2 | |
| SCHEMBL5653982 | 0.77 | PDCD1 (0.49) | — | |
| Hydrochloric Acid SCHEMBL5966887 | 0.77 | SCN9A (0.56) | MAPTL3MBTL1SCN9AMAOBMAOA | |
| SCHEMBL8843830 | 0.77 | EPHX1 (0.51) | ATM | |
| SCHEMBL5653973 | 0.77 | PDCD1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196429-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-12 | — | — | WO | disclosed |
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |