Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | ANPEP | P15144 | 3/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24324140 | 1.00 | DPP4 (0.41) | DPP4ANPEPENPEPALOX5METAP1 | |
| SCHEMBL82667 | 0.98 | DPP4 (0.42) | DPP4ANPEPENPEPALOX5METAP1 | |
| SCHEMBL2585787 | 0.98 | DPP4 (0.42) | DPP4ANPEPENPEPALOX5METAP1 | |
| SCHEMBL2859771 | 0.98 | DPP4 (0.42) | DPP4ANPEPENPEPALOX5METAP1 | |
| Hydrochloric Acid SCHEMBL8815090 | 0.95 | DPP4 (0.41) | DPP4ANPEPENPEPALOX5METAP1 | |
| Hydrochloric Acid SCHEMBL629206 | 0.95 | DPP4 (0.41) | DPP4ANPEPENPEPALOX5METAP1 | |
| Hydrochloric Acid SCHEMBL629207 | 0.95 | DPP4 (0.41) | DPP4ANPEPENPEPALOX5METAP1 | |
| SCHEMBL24324582 | 0.95 | — | — | |
| SCHEMBL14889552 | 0.95 | — | — | |
| SCHEMBL3322576 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196429-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-12 | — | — | WO | disclosed |
| CN-116601158-A | Modulators of cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |