⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15049323 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL31707900 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL18109267 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL26087414 | 0.97 | — | — | |
| SCHEMBL24323716 | 0.90 | DPP4 (0.41) | — | |
| SCHEMBL14889552 | 0.90 | — | — | |
| SCHEMBL24324582 | 0.90 | — | — | |
| SCHEMBL24324140 | 0.90 | DPP4 (0.41) | — | |
| SCHEMBL10020213 | 0.89 | ANPEP (0.39) | — | |
| Hydrochloric Acid SCHEMBL28821260 | 0.89 | ANPEP (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084892-A | Compounds useful as HPK1 inhibitors | 深圳福沃药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| EP-3743430-B1 | AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20230041738-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-02-09 | — | — | US | disclosed |
| EP-4097106-A1 | 1H-PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | Bristol-Myers Squibb Company (US) | 2022-12-07 | — | — | EP | disclosed |
| CN-115151547-A | 1H-pyrazolo [4,3-d ] pyrimidine compounds as Toll-like receptor 7 (TLR 7) agonists | 百时美施贵宝公司 | 2022-10-04 | — | — | CN | disclosed |
| WO-2021154668-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-08-05 | — | — | WO | disclosed |
| US-8877756-B2 | Substituted pteridines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-20140322302-A1 | THERAPEUTIC PEPTIDES | COMBIMAB, INC (US) | 2014-10-30 | — | — | US | disclosed |
| EP-2032585-B1 | SUBSTITUTED PTERIDINES AS THERAPEUTIC AGENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-07-23 | — | — | EP | disclosed |
| US-8748575-B2 | Therapeutic peptides | COMBIMAB, INC. (US) | 2014-06-10 | — | — | US | disclosed |
| US-20140038881-A1 | Therapeutic Peptides | COMBIMAB, INC (US) | 2014-02-06 | — | — | US | disclosed |
| EP-2605786-A2 | THERAPEUTIC PEPTIDES | Combimab, Inc. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2011156453-A2 | THERAPEUTIC PEPTIDES | COMBIMAB, INC. (US) | 2011-12-15 | — | — | WO | disclosed |
| US-20100120766-A1 | Substituted Pteridines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-13 | — | — | US | disclosed |
| US-7674788-B2 | 7-amino-6-chloro-2-piperazin-1-yl-4-pyrrolidin-1-yl-pteridine; central nervous system, respiratory, gastrointestinal or inflammatory diseases; joints, skin or eyes diseases; cancer; phosphodiesterase 4 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-20070287704-A1 | 7-amino-6-chloro-2-piperazin-1-yl-4-pyrrolidin-1-yl-pteridine; central nervous system, respiratory, gastrointestinal or inflammatory diseases; joints, skin or eyes diseases; cancer; phosphodiesterase 4 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-13 | — | — | US | disclosed |