Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 16/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21116604 | 0.88 | ATF4 (0.40) | ATF4 | |
| SCHEMBL21116645 | 0.88 | ATF4 (0.40) | ATF4PPARGHRH3 | |
| SCHEMBL24116573 | 0.85 | ATF4 (0.38) | ATF4P2RX7HRH3 | |
| SCHEMBL21116637 | 0.84 | ATF4 (0.38) | ATF4PPARG | |
| SCHEMBL30446243 | 0.83 | ATF4 (0.58) | ATF4 | |
| SCHEMBL19577365 | 0.83 | ATF4 (0.58) | ATF4 | |
| SCHEMBL25965549 | 0.83 | ATF4 (0.37) | ATF4 | |
| SCHEMBL25957659 | 0.82 | ATF4 (0.37) | ATF4 | |
| SCHEMBL21116600 | 0.81 | ATF4 (0.38) | ATF4P2RX7 | |
| SCHEMBL21116463 | 0.79 | ATF4 (0.61) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |