Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24325756 | 0.92 | REN (0.54) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24326677 | 0.92 | REN (0.54) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24325748 | 0.92 | REN (0.54) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24325789 | 0.91 | REN (0.53) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24326156 | 0.91 | REN (0.53) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24325757 | 0.90 | REN (0.50) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24326341 | 0.90 | REN (0.50) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24326674 | 0.89 | PSEN1 (0.53) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24326226 | 0.89 | REN (0.51) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19520884 | 0.81 | PPARA (0.55) | APPACEAKT1CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |