Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | LDHB | P07195 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326409 | 0.84 | MAPT (0.43) | MAPTPKMALDH1A1MAPK1TDP1 | |
| SCHEMBL18581317 | 0.84 | MAPT (0.74) | MAPTPKMALDH1A1CA12CA9 | |
| SCHEMBL21036540 | 0.76 | MAPT (0.56) | MAPTPKMALDH1A1CA12CA9 | |
| SCHEMBL10372847 | 0.74 | MAPT (0.68) | MAPTPKMALDH1A1CA12CA9 | |
| SCHEMBL21613821 | 0.74 | MAPT (0.68) | MAPTPKMALDH1A1CA12CA9 | |
| SCHEMBL10373205 | 0.73 | MAPT (0.63) | MAPTPKMALDH1A1CA12CA9 | |
| SCHEMBL19917852 | 0.72 | MAPT (0.54) | MAPTPKMALDH1A1CA12CA9 | |
| SCHEMBL4697192 | 0.71 | GAA (0.46) | MAPTPKMALDH1A1CA12CA9 | |
| SCHEMBL20683509 | 0.70 | MAPT (0.46) | MAPTPKMALDH1A1MAPK1TDP1 | |
| SCHEMBL19159541 | 0.70 | MAPT (0.59) | MAPTPKMALDH1A1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |