Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326472 | 0.84 | MAPT (0.58) | MAPTPKMALDH1A1LMNAMAPK1 | |
| SCHEMBL21035869 | 0.79 | MAPT (0.46) | MAPTPKMALDH1A1LMNAMAPK1 | |
| SCHEMBL29570525 | 0.78 | MEN1 (0.57) | MAPTPKMALDH1A1LMNAMMP1 | |
| SCHEMBL27012162 | 0.78 | MEN1 (0.57) | MAPTPKMALDH1A1LMNAMMP1 | |
| SCHEMBL29570638 | 0.74 | MET (0.52) | MAPTPKMALDH1A1LMNAMET | |
| SCHEMBL24326075 | 0.74 | USP30 (0.38) | PKMALDH1A1MMP1MMP9USP30 | |
| SCHEMBL14990419 | 0.72 | ROCK2 (0.50) | ALDH1A1LMNAMMP1MMP9MMP13 | |
| SCHEMBL14990420 | 0.72 | ROCK2 (0.50) | ALDH1A1LMNAMMP1MMP9MMP13 | |
| SCHEMBL744261 | 0.71 | USP30 (0.54) | MAPTALDH1A1LMNABTKMAPK1 | |
| SCHEMBL744262 | 0.71 | USP30 (0.54) | MAPTALDH1A1LMNABTKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |