Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326634 | 0.83 | TDP1 (0.69) | TDP1ATML3MBTL1HDAC2HDAC8 | |
| SCHEMBL24326619 | 0.82 | S1PR2 (0.49) | TDP1ATML3MBTL1HDAC2HDAC8 | |
| SCHEMBL22280327 | 0.82 | PLK1 (0.59) | HDAC2HDAC8HDAC1LMNASMN1; SMN2 | |
| SCHEMBL24326051 | 0.82 | TDP1 (0.68) | TDP1ATML3MBTL1HDAC2HDAC8 | |
| SCHEMBL28869644 | 0.82 | SIRT2 (0.75) | TDP1ATML3MBTL1HDAC2HDAC8 | |
| SCHEMBL12611874 | 0.81 | MAPT (0.67) | TDP1ATML3MBTL1HDAC8HDAC1 | |
| Hydrochloric Acid SCHEMBL26691018 | 0.80 | S1PR1 (0.64) | TDP1ATML3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL16975850 | 0.80 | SMN1; SMN2 (0.71) | TDP1ATML3MBTL1HDAC2HDAC8 | |
| SCHEMBL14679168 | 0.78 | TDP1 (0.62) | TDP1ATML3MBTL1HDAC2HDAC8 | |
| SCHEMBL11920075 | 0.78 | TDP1 (0.62) | TDP1ATML3MBTL1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022056042-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2022-03-17 | — | — | WO | disclosed |