Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.40 |
| ▸ | SDHB | P21912 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326460 | 0.88 | HSP90AA1 (0.40) | SDHBMEN1POLBKMT2APAX8 | |
| SCHEMBL4444719 | 0.78 | PPID (0.36) | CRHR1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL24298823 | 0.77 | L3MBTL1 (0.39) | HSP90AA1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL4439238 | 0.74 | SMN1; SMN2 (0.36) | POLBKMT2AACACBACACAHSP90AA1 | |
| SCHEMBL22502015 | 0.74 | HSP90AA1 (0.41) | PAX8ACACBACACAHSP90AA1 | |
| SCHEMBL24309477 | 0.73 | HSP90AA1 (0.36) | PAX8ACACBACACAHSP90AA1 | |
| SCHEMBL29566720 | 0.73 | HSP90AA1 (0.36) | PAX8ACACBACACAHSP90AA1 | |
| SCHEMBL4437706 | 0.72 | TRPV1 (0.42) | POLBNPSR1TACR3 | |
| SCHEMBL1881782 | 0.71 | SSTR4 (0.37) | MEN1KMT2APAX8 | |
| SCHEMBL22304529 | 0.70 | ADORA2A (0.38) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |