Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 14/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | PLK1 | P53350 | 1/20 | 0.62 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576095 | 0.88 | POLB (0.72) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL3306850 | 0.86 | TSHR (0.72) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL24327629 | 0.82 | RAB9A (0.56) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL24326860 | 0.81 | NEK2 (0.73) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL3655128 | 0.78 | NEK2 (0.55) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL3651706 | 0.76 | POLB (0.53) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL24326760 | 0.74 | NEK2 (0.70) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL8085658 | 0.72 | POLB (0.72) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL12911751 | 0.72 | POLB (0.72) | NEK2AURKACDK1PLK1NEK7 | |
| SCHEMBL4514851 | 0.72 | POLB (0.72) | NEK2AURKACDK1PLK1NEK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225304-B1 | SYNTHESIS OF EGFR MODULATORS | UNIV MICHIGAN REGENTS (US) | 2025-12-17 | — | — | EP | disclosed |
| US-20240018144-A1 | Synthesis of EGFR Modulators | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-01-18 | — | — | US | disclosed |
| US-20240018144-A1 | Synthesis of EGFR Modulators | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-01-18 | — | — | US | disclosed |
| US-20240018144-A1 | Synthesis of EGFR Modulators | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-01-18 | — | — | US | disclosed |
| CN-116997551-A | Synthesis of EGFR modulators | 密歇根大学董事会 | 2023-11-03 | — | — | CN | disclosed |
| EP-4225304-A1 | SYNTHESIS OF EGFR MODULATORS | The Regents of The University of Michigan (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022081514-A1 | SYNTHESIS OF EGFR MODULATORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081514-A1 | SYNTHESIS OF EGFR MODULATORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022077154-A1 | SYNTHESIS OF EGFR MODULATORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022077154-A1 | SYNTHESIS OF EGFR MODULATORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018144-A1 | Synthesis of EGFR Modulators | EGFR, ERBB2, ERBB4 | NEK2 740/4885AURKA 231/4885CDK1 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.