Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326993 | 0.94 | ALOX12 (0.44) | ALOX12CNR2HTR2CHTR2BALDH1A1 | |
| SCHEMBL14591313 | 0.80 | ALOX12 (0.47) | ALOX12CNR2HTR2CHTR2BALDH1A1 | |
| SCHEMBL24326990 | 0.77 | MAPT (0.46) | ALOX12CNR2ALDH1A1HTTMEN1 | |
| SCHEMBL24328575 | 0.76 | ALOX12 (0.44) | ALOX12CNR2HTR2CHTR2BALDH1A1 | |
| SCHEMBL24328578 | 0.76 | ALOX12 (0.44) | ALOX12CNR2HTR2CHTR2BALDH1A1 | |
| SCHEMBL24328580 | 0.76 | KDM4E (0.55) | ALOX12CNR2HTR2CHTR2BALDH1A1 | |
| SCHEMBL24328583 | 0.75 | ALOX12 (0.43) | ALOX12CNR2HTR2CHTR2BALDH1A1 | |
| SCHEMBL14591325 | 0.74 | ALOX12 (0.56) | ALOX12ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL24326991 | 0.73 | ALOX12 (0.42) | ALOX12CNR2ALDH1A1HTTMEN1 | |
| SCHEMBL24327001 | 0.71 | KMT2A (0.63) | ALOX12ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |